GcMAF is a vitamin D-binding protein and is scientifically known as Gc protein-derived macrophage activating factor. It is a protein found in different body fluids (serum, urine, breast milk, ascitic fluid, cerebrospinal fluid, saliva and seminal fluid) and organs (brain, heart, lungs, kidneys, placenta, spleen, testes
Although its major function is binding, solubilization and transport of vitamin D and its metabolites, this glycoprotein exhibits numerous other important biological functions in the body.
GcMAF activates macrophage cells, or the cells responsible for fighting off infection, such as viruses and diseases such as cancer. Cancer cells and tumors release a protein called nagalase. When released, it prevents immune system cells from functioning properly by blocking GcMAF protein.
The articles herein (none of which have been retracted) describe current GcMAF research and discuss its multifunctional capacity - particularly, its ability to enhance cellular immunity in cultures and animal models.