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Bioregulatory systems medicine is a paradigm that aims to advance current medical practices. The basic scientific and clinical tenets of this approach embrace an interconnected picture of human health, supported largely by recent advances in systems biology, genomics, and physics and focus on the implications of multi-scale interconnectivity for improving therapeutic approaches to disease.


The foundation of the bioregulatory systems medicine model is an appreciation of the patient's autoregulatory capacity. Whereas human biology exists as nested levels of physiological networks, i.e., molecular, cellular, tissue, organ, system, etc., the autoregulatory capacity includes both the specific networks within this hierarchy as well as the interactions between them.


Thus, bioregulatory systems medicine embraces this interconnectivity among networks as the global autoregulatory network and posits that the state of an individual's autoregulatory network is a key determinant and indicator of patient health. Bioregulatory treatment represents a personalized approach through a multifaceted therapeutic process. This approach involves all levels of being (structural, biochemical, functional, energetic, psychoemotional) and assists (not suppresses) the bioregulatory and adaptive networks of the body.

The following are selected articles on bioregulatory systems medicine.

Ahn Andrew C,  Muneesh Tewari, Chi-Sang Poon, and Russell S Phillips. The Limits of Reductionism in Medicine: Could Systems Biology Offer an Alternative? PLoS Med. 2006 Jun; 3(6): e208 doi:  10.1371/journal.pmed.0030208


Barabási, Albert-László, Natali Gulbahce, and Joseph Loscalzo. "Network medicine: a network-based approach to human disease." Nature reviews genetics 12, no. 1 (2011): 56-68.

Barabasi, Albert-Laszlo, and Zoltan N. Oltvai. "Network biology: understanding the cell's functional organization." Nature reviews genetics 5, no. 2 (2004): 101-113.

Baffy, György, and Joseph Loscalzo. "Complexity and network dynamics in physiological adaptation: an integrated view." Physiology & behavior 131 (2014): 49-56.

Bosh Tatyana. New Medical Paradigm: Bioregulatory Medicine. Townsend Journal; January 2011.


Bosh, Tatyana. "Bioregulatory Psychosomatic Bodywork." (2013).


Burmeister AW, Y, Cesnulevicius K, Herbert M, Kane M, Lescheid D, McCaffrey T, Schultz M, Seilheimer B, Smit A, St Laurent G 3rd, Berman B. Bioregulatory systems medicine: an innovative approach to integrating the science of molecular networks, inflammation, and systems biology with the patient's autoregulatory capacity? Front Physiol. 2015 Aug 19;6:225. doi: 10.3389/fphys.2015.00225. eCollection 2015.


Chovatiya, Raj, and Ruslan Medzhitov. "Stress, inflammation, and defense of homeostasis." Molecular cell 54, no. 2 (2014): 281-288.

Deneef, Jacques. "Treatment with Bioregulatory Medications." Journal of Biomedical Therapy 4, no. 2 (2010).

Furlong, Laura I. "Human diseases through the lens of network biology." Trends in genetics 29, no. 3 (2013): 150-159.

Goldman, Alyssa W., Yvonne Burmeister, Konstantin Cesnulevicius, Martha Herbert, Mary Kane, David Lescheid, Timothy McCaffrey et al. "Bioregulatory systems medicine: an innovative approach to integrating the science of molecular networks, inflammation, and systems biology with the patient's autoregulatory capacity?." Frontiers in physiology 6 (2015): 225.


Gibson, Greg, and Peter M. Visscher. "From personalized to public health genomics." Genome medicine 5, no. 7 (2013): 60.

Hood L, M.D., Ph.D. Systems Biology and P4 Medicine: Past, Present, and Future. Rambam Maimonides Med J. 2013 Apr; 4(2): e0012. Published online 2013 Apr 30. doi:  10.5041/RMMJ.10112

Kulikov, V. I., and G. I. Muzya. "The bioregulatory role of platelet-activating factor in intracellular processes and cell-cell interactions." Biochemistry-New York-English Translation of Biokhimiya 63, no. 1 (1998): 47-54.

Loscalzo, Joseph, and Albert‐Laszlo Barabasi. "Systems biology and the future of medicine." Wiley Interdisciplinary Reviews: Systems Biology and Medicine 3, no. 6 (2011): 619-627.

Oken, Barry S., Irina Chamine, and Wayne Wakeland. "A systems approach to stress, stressors and resilience in humans." Behavioural brain research 282 (2015): 144-154.

Oken, Barry S. "A Systems Approach to Stress and Resilience in Humans: Mindfulness Meditation, Aging, and Cognitive Function." (2016).

Rubik, Beverly. "The biofield hypothesis: Its biophysical basis and role in medicine." The Journal of Alternative & Complementary Medicine 8, no. 6 (2002): 703-717.

Van der Waaij, D. "Bioregulation of the digestive tract microflora." Rev. sci. tech. Off. int. Epiz 8 (1989): 333-345.

Vidal, Marc, Michael E. Cusick, and Albert-László Barabási. "Interactome networks and human disease." Cell 144, no. 6 (2011): 986-998.

Wang X, Zhang A, Sun H, Wang P. Systems biology technologies enable personalized traditional Chinese medicine: a systematic review. Am J Chin Med. 2012; 40(6):1109-22

Yan, Qing. "Toward dynamical systems medicine: personalized and preventive strategies." (2017): 551-554.


Yarovaya, G. A., T. B. Blokhina, and E. A. Neshkova. "Contact system. New concepts on activation mechanisms and bioregulatory functions." Biochemistry (Moscow) 67, no. 1 (2002): 13-24.

Zhang A, Sun H, Yan G, Cheng W, Wang X. Systems biology approach opens door to essence of acupuncture. 
Complement Ther Med. 2013 Jun; 21(3):253-9. Epub 2013 Mar 25.

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