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Lingering Safety Concerns Reveal the mRNA COVID-19 Inoculations Could Have Altered Your Genome

James Odell, OMD, ND, LAc

Covid-19 vaccine

The mRNA COVID-19 inoculations have been the subject of safety concerns and several controversies since their inception. Among the many safety concerns, and one of the most concerning, was their potential to be incorporated into the human genome or alter human DNA (elicit genotoxicity). 

This article outlines recent research demonstrating that COVID-19 injections are likely, in some cases, to be reverse transcribed into the recipient’s DNA. 

Essentially, the components that make you YOU, have been changed, making your blueprint different from the genome given to you at birth. Astoundingly, to date, there are no published safety studies on biodistribution, cellular uptake, endosomal escape, translation rates, functional half-life, and inactivation kinetics of synthetic mRNA inoculation.

1. Biodistribution: Biodistribution refers to the study of how a substance is distributed in the body after administration. In the case of synthetic mRNA, it involves understanding where the mRNA is distributed in the body after inoculation.

2. Cellular uptake: Cellular uptake is the process by which cells absorb materials from the external environment. In the context of synthetic mRNA, it refers to the uptake of the mRNA by the body’s cells after administration.

3. Endosomal escape: Endosomal escape is the ability of a substance, such as synthetic mRNA, to escape from the endosome, a membrane-bound compartment inside cells. This is important for the mRNA to reach the cell’s cytoplasm, where it can be translated into protein.

4. Translation rates: Translation rates refer to the speed at which the cell translates the genetic information carried by the mRNA into proteins. It is a measure of how efficiently the mRNA is used by the cell to produce proteins.

5. Functional half-life: The functional half-life of a substance is the time it takes for half of the substance to lose its functionality or effectiveness. In the case of synthetic mRNA, it refers to the duration for which the mRNA remains functional in the body.

6. Inactivation kinetics: Inactivation kinetics involves studying the rate at which a substance, such as synthetic mRNA, loses its activity or is deactivated in the body. 

A Lack of Safety research

This lack of safety research should be a major concern since billions of people were inoculated with the experimental COVID mRNA genetic material, many of which were forcefully mandated. Due to the experimental nature of these mRNA inoculations, terrifyingly, the public is being used as the phase 3 clinical study.

2021 Study Shows That the SARS-CoV-2 RNAs Can Be Reverse-Transcribed

 Early on there was the assumption that there is no possibility of genomic integration of synthetic mRNA. However, a 2021 study published in the Proceedings of the National Academy of Sciences showed that SARS-CoV-2 RNAs can be reverse-transcribed and integrated into the genome of cultured human cells. 1

This caused quite a stir in the scientific community and gave rise to the question that this may be occurring with the Pfizer mRNA BNT162b2 and Moderna mRNA-1273 inoculation. Researchers and doctors who honestly looked at the study were raising alarm bells at the time and warning that these inoculations should be stopped until further information is known. 

However, the entire mainstream media, government officials, and pharmaceutical-sponsored fact checkers, immediately jumped onto this adamantly claiming that not under any circumstances could COVID-19 injections alter a person’s DNA.

“Unlikely” or “Low Probability” Versus “Impossible”

Some organizations have been silent or somewhat careful in their commentaries to use the terms “unlikely” and “low probability” instead of “impossible” since we are not certain what the technology is that is being employed and may change from batch

to batch.

Another Concerning Study

Another damming in vitro study published in 2022 entitled Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line, also showed the entry of COVID inoculation BNT162b2 into the cells

and subsequent intracellular reverse transcription of BNT162b2 mRNA into DNA. 2

Concerning Conclusions

Based on this study, many scientists and physicians concluded that the genetic material could indeed be incorporated into the recipient’s DNA. The authors concluded, Our study is the first in vitro study on the effect of COVID-19 mRNA vaccine BNT162b2 on human liver cell line. We present evidence on fast entry of BNT162b2 into the cells and subsequent intracellular reverse transcription of BNT162b2 mRNA into DNA. This study was supported by the Swedish Research Council, Strategic Research Area Exodiab, Dnr 2009-1039, the Swedish Government Fund for Clinical Research (ALF), and the foundation of Skåne University Hospital. 

This study should have signaled a major safety concern, given the possibility of synthetic mRNA-driven epigenetic and genomic modifications arising. These findings are very unsettling and show that some vaccinated people experience forced alteration of their genomes with spike protein-producing code permanently residing in the affected cells.

Media and Government Agencies Denials

Even after this study showed that it is more than a possibility that synthetic mRNA genetic material can be incorporated into the human genome and alter human DNA in certain cases, media and government agencies continue to deny this as a concern.

Criticisms of this study were circulated widely throughout the internet. 3

Joseph Ladapo’s Call for Stopping the Use of mRNA Injections

In January 2024, Florida Surgeon General Dr. Joseph Ladapo recently issued a press statement, calling for the stop of the use of mRNA injections in human beings due to their ability to modify the human genome. 4 Dr. Ladapo explained how Pfizer’s and the FDA’s lack of proper animal and human testing (bona fide research) is beyond reckless as the mRNA nanoparticle technologies have the capability of introducing oncogenes (genes that cause cancer) as well as making transgenerational changes to the human species. Even more astounding, now Pfizer does not even cover up the fact that their mRNA injections are intended for gene editing, specifically to modify the human genome. 5 

Pfizer website states, “mRNA technology is a good fit for gene editing. We want to make these editing proteins for a short period of time to modify the genome.” – Pfizer

Pfizer states in their FDA-approved license that their mRNA injections edit the genetic makeup of human cells through nucleotide substitution by RNA (modRNA) transcription. 6  

Pfizer product quality manufacturing overview text

NIH genomic substitution documentation

We still do not know how many cells are affected in persons experiencing reverse transcription and integration of the Pfizer or 

Moderna vaccine code into their DNA (and this may vary from batch to batch). We can only hope the mRNA code-carrying cells are a small minority in each inoculated individual. 

The Unknown Effects on Reproduction

We also do not know if reproductive cells, eggs and sperm are affected. Are there any newborns whose germline genes carry these mRNA codes? Further, it appears that hopefully not every inoculated recipient was affected by this reverse integration and therefore, injected individuals have a chance that they were not the ones whose genomes were altered. Certainly, more studies are needed to further understand the extent of this gene editing event. 

Unfortunately, prestigious journals do not like to publish scientific findings critical of COVID-19 inoculations. No doubt fact-checkers will now say “Oh, but it is not everyone that is affected”. Remember, so many government-official media outlets and fact-checkers claimed that this information was false from the outset. Also, remember that the public was initially told that the synthetic mRNA genetic material stayed at the injection site of the arm and would not be biodistributed to the organs or tissues. 

Data Reveals Evidence of Biodistribution

However, regarding biodistribution, the pharmacokinetics data provided by Pfizer to the European Medicines Agency (EMA), on its mRNA gene editing shot’s biodistribution was studied in mice and rats by intra-muscular injection with radiolabeled LNP and luciferase modRNA. Radioactivity was detected in most tissues and results showed that the injection site and the liver were the major sites of distribution, with maximum concentrations observed at 8–48 h post-dose. 7 The Pfizer European Medicines Agency animal study assessment report also showed that BNT162b2 distributes in the spleen (<1.1%), and adrenal glands (<0.1%), as well as low and measurable radioactivity in the ovaries and testes (<0.1%). No data on the placental transfer of BNT162b2 is available from the Pfizer EMA assessment report.  

Liver Effects of Pfizer’s BNT162b2 Injection


Furthermore, in that study animals that received the Pfizer BNT162b2 injection exhibited pathologic liver effects. This included an enlarged liver, vacuolation, increased gamma-glutamyl transferase (γGT) levels, and increased levels of aspartate transaminase (AST) and alkaline phosphatase (ALP). Transient hepatic effects induced by LNP delivery systems have been previously reported. 8, 9, 10, 11

Serious Side Effects Indicate Not “Safe and Effective”

So, it has also been strongly propagated, and continues to be told, that these so-called “vaccines” are “safe and effective”. We now know that side effects are more than rare and include serious clinical manifestations such as acute myocardial infarction, Bell’s palsy, cerebral venous sinus thrombosis, Guillain–Barré syndrome, myocarditis/pericarditis (mostly in younger ages), pulmonary embolism, stroke, thrombosis with thrombocytopenia syndrome, lymphadenopathy, appendicitis, herpes zoster reactivation, neurological complications, and autoimmunity (e.g., autoimmune hepatitis, autoimmune peripheral neuropathies, and sudden death. 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25 

Review of Thousands of Publications Reveals Side Effects After Vaccination Affect Every Organ Without Exception

The all-cause mortality rate is way up from pre-inoculation years and this is a figure that cannot be denied. This January the 11th, 2024 in Japan a group of prestigious scientists and doctors (Japanese General Incorporated Association Vaccine Issues Study Group) held a press conference to report on their systematic review of thousands of publications of scientific literature from the NIH PubMed database and other global databases on synthetic viruses, mRNA gene editing technologies, and ‘lipid’ nanoparticles. During the press conference, Professor Emeritus Masanori Fukushima of Kyoto University stated, 

“A systematic review of the literature has revealed some surprising facts. Side effects after vaccination affect every organ without exception from ophthalmology to general medicine to psychiatry.” He went on to say, “You will find diseases of the heart, kidney, thyroid, diabetes, liver, skin, eyes, blood, nerves, systemic diseases, brain, lungs… diseases across all medical fields have been reported. As my specialty is cancer, chemotherapy drugs are plagued with side effects, but the patterns are known and predetermined. The patterns of the side effects caused by this vaccine are not determined. They can occur throughout the body. The characteristics of this vaccine are that they occur simultaneously within entire families. I believe it (the mRNA COVID-19 injection) should be stopped immediately. The spike is toxic. It is very clear what happens when you administer a toxic gene to a human. Another point is that the lipid nanoparticles are also toxic.” 

A Database of Evidence

Professor Emeritus Masayasu Inoue of Osaka City University stated, 

“We are working with Dr. Fukushima to create this database. So far, about 201 types of disease and 3,071 papers on side effects have been reported. It is unprecedented in human history for a single vaccine to have this much (harmful) literature out on it. With this, we plan to present to the nation and the Japanese government in the form of solid science that one cannot dispute. You will find diseases of the heart, kidney, thyroid, diabetes, liver, skin, eyes, blood, nerves, systemic diseases, brain, and lungs… diseases across all medical fields have been reported. As Prof. Fukushima stated, the characteristic of this vaccine is that they occur simultaneously within entire families. 26 

Lastly, by falsely referring to injectable gene editing technologies as ‘vaccines,’ Pfizer, the FDA, and the NIH knowingly lied to the American people and global civilians. We were told to simply trust the science and the experts. Unfortunately, nearly none of the experts have been honest with people of the world. 


1. Zhang, Liguo, Alexsia Richards, M. Inmaculada Barrasa, Stephen H. Hughes,

  1. Richard A. Young, and Rudolf Jaenisch. "Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues." Proceedings of the National Academy of Sciences 118, no. 21 (2021): e2105968118. 2. Aldén, Markus, Francisko Olofsson Falla, Daowei Yang, Mohammad Barghouth, Cheng Luan, Magnus Rasmussen, and Yang De Marinis. "Intracellular reverse transcription of Pfizer BioNTech COVID-19 mRNA vaccine BNT162b2 in vitro in human liver cell line." Current issues in molecular biology 44, no. 3 (2022): 1115-1126. 3045/44/3/73/htm?&sznclid=22fc4a625ce94af5bc61420a4f36cf58 Abstract: Preclinical studies of COVID-19 mRNA vaccine BNT162b2, developed by Pfizer and BioNTech, showed reversible hepatic effects in animals that received the BNT162b2 injection. Furthermore, a recent study showed that SARS-CoV-2 RNA can be reverse-transcribed and integrated into the genome of human cells. In this study, we investigated the effect of BNT162b2 on the human liver cell line Huh7 in vitro. Huh7 cells were exposed to BNT162b2, and quantitative PCR was performed on RNA extracted from the cells. We detected high levels of BNT162b2 in Huh7 cells and changes in gene expression of long interspersed nuclear element-1 (LINE-1), which is an endogenous reverse transcriptase. Immunohistochemistry using antibody binding to LINE-1 open reading frame-1 RNA-binding protein (ORFp1) on Huh7 cells treated with BNT162b2 indicated increased nucleus distribution of LINE-1. PCR on genomic DNA of Huh7 cells exposed to BNT162b2 amplified the DNA sequence unique to BNT162b2. Our results indicate a fast up-take of BNT162b2 into human liver cell line Huh7, leading to changes in LINE-1 expression and distribution. We also show that BNT162b2 mRNA is reverse transcribed intracellularly into DNA in as fast as 6 h upon BNT162b2 exposure. 3. Merchant, Hamid A. "Comment on Aldén et al. 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