Vitamin D Binding Protein (VDBP), also known as Gc protein, is a multifunctional protein whose main role is to carry vitamin D and its metabolites, but it also acts as an actin scavenger and is the precursor of the macrophage activating factor molecule (GcMAF), which has reported highly promising results against cancer, HIV, and neurological disorders including autism, Alzheimer's disease, Chronic Fatigue Syndrome (CFS), among others.
In short, many diseases are associated with increased levels of nagalase, which deglycosylates VDBP so it cannot convert to GcMAF, thus leading to immunosuppression. Very few laboratories offer testing for Nagalase.
RED Laboratories is a private Belgian company, focused on developing and performing specialty research and diagnostic tests - including a Nagalese Activity Assay: Nagalase (n-acetylgactosaminidase) is an enzyme that deglycosylates the Gc protein also known as vitamin D binding protein (VDBP). The Gc protein is thereby rendered incapable of conversion into active GcMAF. As a result, the regulation of macrophage activation is prevented. For more on RED Laboratories and their Nagalese test: http://www.redlabs.com/naa A healthy level of Nagalase is below 0.62 nmol/min/mg.